Causes and solutions for bladder adenocarcinoma
Bladder adenocarcinoma is a common tumor disease in life, but what is the cause of the disease in most people?
So how to treat bladder adenocarcinoma?
Causes of bladder adenocarcinoma 1. Long-term exposure to certain carcinogens engaged in printing and dyeing, textile, leather manufacturing, rubber, paint, plastics, etc., long-term exposure to benzidine, β-naphthylamine, 4-amino doubleCarcinogenic substances such as benzene, so the risk of developing bladder adenocarcinoma is significantly higher than other people.
Because the individual’s susceptibility to the above substances is quite different, it shows an incubation period of 15 to 40 years.
2, chronic infection of the bladder and long-term stimulation of bladder stones, bladder diverticulum, schistosomiasis cystitis and other chronic infections and foreign body irritation, will increase the risk of bladder adenocarcinoma.
3. Smoking is the most common carcinogenic factor.
About 35% of patients with bladder adenocarcinoma are related to smoking. The incidence and severity are linear with the amount of daily smoking and the length of smoking. This is related to the carcinogenesis of tobacco derivatives containing various aromatic amines.
4, other long-term use of analgesics phenacetin, endogenous tryptophan metabolism abnormalities, etc., can also be called the cause or predisposing factors of bladder adenocarcinoma.
Solution for bladder adenocarcinoma I. Partial resection of the bladder Partial resection of the bladder has been more than 100 years old. It has been widely used before the TURBt operation. This operation is simple and can preserve the bladder function and is easy for patients to accept.
Indications: mainly for superficial bladder adenocarcinoma with large tumor, wide pedicle or TURBt, no local exudative bladder adenocarcinoma without distant metastasis, bladder diverticulum carcinoma and tumor are T2, T3a invasiveBladder adenocarcinoma, but patients who refuse complete bladder resection are relatively contraindicated: carcinoma in situ, recurrence or multiple tumors, tumors beyond the bladder wall, invasion of the bladder neck or prostate, bladder volume after tumor resection is too small (less than normal 1/3) andThe patient’s physical condition is extremely poor.
The 5-year survival rate of partial cystectomy is 60% to 75% in patients with T2 and T3a, and the incidence of postoperative tumor metastasis is 1% to 3%.
Second, total cystectomy indications for total cystectomy include 1. Invasive bladder adenocarcinoma (T2 and T3), especially when the tumor diameter is >3cm, multiple, ureteral obstruction, prostate invasion, bladder baseTumor.
2, multiple papillary tumors (Ta and T1), repeated recurrence of superficial bladder adenocarcinoma with severe mucosal lesions, combined with extensive carcinoma in situ, rapid recurrence and increased malignancy.
Pelvic lymphadenectomy after cystectomy can determine the stage of bladder adenocarcinoma to estimate the prognosis, because when there is pelvic lymph node metastasis, there is more distant metastasis.
Total cystectomy should be performed in conjunction with urethral diversion surgery. The risk of surgery is large. It is easy to have postoperative infection complications. The patient’s physical condition should be fully evaluated before surgery. The general method after surgery is to hang the urine bag. The patient needs a certain time.Adapt to the process.